Arsenal lost for just the second time in the Premier League this season after Ashley Williams headed home Ross Barkley's corner in the 86th minute.
Alexis Sanchez had given the visitors a 20th-minute lead at Goodison Park before Seamus Coleman equalised for Everton in the second half.
The defeat not only ended Arsenal's remarkable 17-match league unbeaten streak on Tuesdays, but it allowed Chelsea the opportunity to potentially move six points clear atop the table.
And It does not get any easier for Arsenal, who make the trip to Pep Guardiola's City on Sunday.
Arsenal are four points clear of City in second position and Cech said: "You have to pick yourself up. There is a big period coming up now with the games coming thick and fast and there is no time to dwell on the defeat. You have to move on and get ready for the next one.
"Sometimes I think it is best if after a big game you play another big game.
"You have opportunities to win, it's a kind of a six-pointer - it's probably a perfect game for us.
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